Beckers nevus syndrome with bilateral skin involvement. They were first recognized clinically as large atypical moles seen in members of two melanoma. Sun exposure is a causative factor, particularly in childhood. In blue nevus pigmentproducing cells are spindled and fusiform dendritic cells.
Soeprono teaches and practices dermatopathology at loma linda university, school of medicine, department of dermatology. It is characterized by the presence of nevus cell nests in the basilar region of epithelium. Smooth muscle hamartoma associated with beckers nevus. Beckers naevus is a birthmark that appears in adolescence or the twenties as a flat brown discolouration in which darker thicker hairs may later grow. Systematized becker nevus in a female ommega online.
Beckers nevus beckers melanosis pathology outlines. Histopathology of beckers nevus reveals acanthosis, basal layer. After 2 months of treatment, all the acne lesions subsided. Giant congenital beckers nevus overlying a plexiform. Syndromes associated with epidermal nevi also are described. Becker s naevus with localized lipoatrophy and ipsilateral breast hypoplasia. Introduction beckers naevus pigmented hairy epidermal naevus, a variety of epidermal naevus, is present in about 0. May 24, 2018 van gerwen hj, koopman rj, steijlen pm, happle r. Becker s nevus syndrome is a part of epider mal nevus syndrome, which is a disease complex of epider mal nevi and developmental abnormalit ies of different organ sys.
Both males and females are affected, though the incidence of beckers nevus is much higher in males compared to females. Becker s nevus melanosis is usually found in the region of the shoulder girdle of young men as unilateral, hyperpigmented areas of somewhat thickened skin. Ilamaran department of paediatrics, melmaruvathur adhiparasakthi institute of medical sciences and research, tamilnadu, india abstract becker s nevus, also called becker s melanosis or pigmented hairy epidermal nevus, is a be. There are several different types of epidermal nevi, including keratinocyte epidermal nevi, nevus sebaceous, nevus comedonicus, and becker nevus.
Smooth muscle hamartoma is congenital whereas beckers nevus has its onset later. Apr 06, 2016 becker s nevus or becker s melanosis is a relatively common benign condition, which presents as a localized hypermelanosis and hypertrichosis. Becker nevus syndrome is a phenotype characterized by the fundamental presence of becker s nevus with ipsilateral hypoplasia of the breast or other skin, skeletal. Careful examination is required because similar type of focal proliferation of melanocytes junctional cavity occurs in melanoma. They are separated and parallel to the normal overlying epithelium.
An unusual presentation in a sunprotected area find, read and cite all the. Beckers nevus syndrome is part of the epidermal nevus syndromes and has been described with a phenotype that includes beckers nevus, ipsilateral breast hypoplasia, and variable skeletal malformations. Beckers nevus is a sharply demarcated tan to brown patch or slightly raised verrucous plaque that most commonly appears on the shoulder, chest, or upper back. While it is generally considered an acquired rather than congenital disorder, there exists at. Giant congenital beckers nevus overlying a plexiform neurofibroma.
It is due to an overgrowth of the epidermis upper layers of the skin, pigment cells melanocytes and hair follicles. Pathology outlines beckers nevus beckers melanosis. Usually beginning as a light to dark brown patch on one side of the body typically the back, shoulder, or chest, beckers nevus can look similar to a birthmark. Pigmentation is usually uniform and well demarcated, but reticulated patches may be present. Beckers nevus genetic and rare diseases information. Clinically and histologically the lesions resemble beckers nevi with the exception that on histologic examination a hamartomatous proliferation of smooth muscle is prominent.
Beckers nevus coexistent with connectivetissue nevus. Dysplastic naevi are benign melanocytic naevi that are defined both histologically and clinically. Thus the pathophysiology of becker s nevus remains unclear. Biopsy from the hyperpigmented macule showed elongated and squared rete ridges with basal layer hyperpigmentation, suggestive of beckers nevus.
Update on epidermal nevi and associated syndromes springerlink. Beckers nevus syndrome is an association of beckers nevus with unilateral breast hypoplasia and muscle, skin, andor skeletal abnormalities. Becker s nevus is a lateonset birthmark tan to brown in color that occurs mostly in males on the shoulder, chest, or upper back. Ilamaran department of paediatrics, melmaruvathur adhiparasakthi institute of medical sciences and research, tamilnadu, india abstract beckers nevus, also called beckers melanosis or pigmented hairy epidermal nevus, is a be. Skin nonmelanocytic tumor beckers nevus beckers melanosis first described by becker in 1948 arch dermatol 1948. A beckers nevus typically begins to develop around puberty on the shoulder or upper trunk, although it may develop on other areas of the body. Medical knowledge and documentation of this disorder is poor, likely due to a combination of factors including recent discovery, low prevalence, and the more or less aesthetic nature of the effects of the skin disorder. A point mutation in the braf gene most often v600e is usually the initiating genetic mutation. Skin nonmelanocytic tumor becker s nevus becker s melanosis first described by becker in 1948 arch dermatol 1948.
Beckers nevus symptoms, diagnosis, treatments and causes. Histopathology skin, kidney systemic sclerosis scleroderm duration. Beckers nevus results from the overgrowth of pigment cells, epidermal cells, and hair follicles. Becker s nevus usually appears as a large brown patch that becomes darker and more hairy after puberty. It develops during childhood or adolescence on the shoulders or upper. These features confirmed the diagnosis of beckers nevus with acne vulgaris. Becker s nevus syndrome is an association of becker s nevus with unilateral breast hypoplasia and muscle, skin, andor skeletal abnormalities. The intradermal nevus is in the large group common nevus. Picture of skin diseases and problems beckers nevus. The patient was being followed without any special. Becker s nevus or becker s melanosis is a relatively common benign condition, which presents as a localized hypermelanosis and hypertrichosis. Histopathology from all the lesion are compatible with beckers nevus.
Age and sex distribution beckers nevus is an infrequentlyoccurring benign skin condition that is observed during early childhood or adolescence. Beckers nevus among siblings pai vv, shukla p, bhobe m. In the oral cavity these are known as intramucosal nevi. Becker s nevus results from the overgrowth of pigment cells, epidermal cells, and hair follicles. They have no tendency to transform into malignant lesion. Based on the clinical and histopathologic characters, a diagnosis of beckers nevus syndrome was formed.
We here report a case of a 15 yearold female who presented with bilateral becker s nevus over her groins, thighs, vulva, and in front of the neck from the age of 5 years. More detailed information about the symptoms, causes, and treatments of becker s nevus is available below. Pigmentation darkening of skin color may be subtle at first, but the nevus often darkens after puberty and expands. Dermatoscopy of beckers nevus nair pa, modasia k, bhavsar n. In such cases, the area of becker s melanosis may show slight perifollicular papular elevations or slight induration. Beckers nevus usually appears as a large brown patch that becomes darker and more hairy after puberty. Soepronos textbook is available on and includes detailed information on over 600 entities and includes four dvd diskettes with highresolution images that provide a virtual. They proposed that beckers nevus could be considered a component of the androgen receptor hypersensitivity syndrome spectrum. Malignant tumours may arise within a nevus sebaceous. It develops during childhood or adolescence on the shoulders or upper trunk, occasionally elsewhere.
Beckers nevus, also known as becker melanosis, is a skin condition that typically affects men and manifests during or after the onset of puberty. Beckers nevus coexistent with connectivetissue nevus jama. Beckers nevus histopathology loma linda dermatopathology. It is part of the nevus comedonicus syndrome, a neurocutaneous disorder with ocular, skeletal, and central nervous symptoms. A 19 yearold female patient had multiple becker nevi at right arm, right mid. Jul 31, 20 dermatopathology reference describes nevus spilus congenital speckled lentiginous nevus histopathology including histologic features and provides links to additional medical references. Beckers naevus with localized lipoatrophy and ipsilateral breast hypoplasia. Becker nevus itself is typically localized on the upper trunk, scapular or upper arm unilaterally. Becker nevus syndrome is a phenotype characterized by the fundamental presence of beckers. David weedon ao md frcpa fcaphon, in weedons skin pathology. Ns clinically presents as a yellowishorange, hairless plaque on the scalp, face, or neck, while bn presents as a tantobrown hyperpigmented, sometimes hypertrichotic, plaque typically on the chest and shoulder.
Overall, histopathology was suggestive of neurofibroma. Of interest is the association of a pilar smooth muscle hamartoma with beckers melanosis. Clinical, dermoscopic and histopathological evaluation of. On clinicopathologic correlation, diagnosis of giant beckers nevus overlying a plexiform neurofibroma was made. Commonest histopathological association of beckers nevus is smooth muscle hamartoma. Histopathological examination of skin lesion demonstrated features of beckers melanosisthe epidermis showing mild acanthosis and. Pdf nevus sebaceus ns and beckers nevus bn are two variants of. Becker s nevus associated with basal cell carcinoma. Soepronos textbook is available on and includes detailed information on over 600 entities and includes four dvd diskettes with highresolution images that provide a virtual dermatopathology reference and guide. Becker nevus syndrome refers to a rare disorder comprising the typical pigmented lesion and its associated developmental abnormalities.
Dec 23, 2009 the term dysplastic naevus was then proposed and remains the term in most common use. No nevus cells found in surround connective tissue. This article highlights the varied clinical and histologic features of epidermal nevi, discusses recent data on pathogenesis, and provides an update on treatment options. While it is generally considered an acquired rather than congenital disorder, there exists at least one case report documenting what researchers claim is a congenital becker s nevus with genetic association. Trichoblastoma is the most common neoplasm developed in nevus sebaceus of jadassohn. The resulting birthmark is usually large, brown, and on one side of the body. Two cases of smooth muscle hamartoma with beckers nevus are reported. Intradermal nevus abbreviated idn, also intradermal melanocytic nevus, is a common benign melanocytic lesion.
Sep 15, 2016 becker s nevus is a noncancerous, large, brown birthmark occurring mostly in males. Pdf on feb 1, 2017, priyadarshini sahu and others published beckers nevus associated with basal cell carcinoma. Beckers nevus melanosis is usually found in the region of the shoulder girdle of young men as unilateral, hyperpigmented areas of somewhat thickened skin. A becker naevus nevus in american spelling is a lateonset epidermal naevus or birthmark occurring mostly in males. We here report a case of a 15 yearold female who presented with bilateral beckers nevus over her groins, thighs, vulva, and in.
This common lesion is usually followed by overlying hypertrichosis within 2 years and occurs most frequently in boys fig. Clinical, dermoscopic and histopathological evaluation of the. In such cases, the area of beckers melanosis may show slight perifollicular papular elevations or slight induration. Beckers nevus or beckers melanosis is a relatively common benign condition, which presents as a localized hypermelanosis and hypertrichosis. Thus the pathophysiology of beckers nevus remains unclear. Beckers melanosis, also known as becker nevus, is a relatively common, usually affects young males, singular, cutaneous hamartoma, which is classically characterized by a unilateral hyperpigmented, hypertrichotic patch on the upper trunk or proximal upper extremities, with its onset during the peripubertal years. Becker nevus compared with unaffected skin fibroblasts. Beckers nevus associated with chromosomal mosaicism and congenital adrenal hyperplasia. Histopathological features of becker nevi include epidermal acanthosis. Histopathological features of beckers nevi include epidermal acanthosis, regular elongation and fusion of rete ridges, hyperpigmentation of the basal layer, and. Of interest is the association of a pilar smooth muscle hamartoma with becker s melanosis. It typically presents unilaterally and is frequently associated with overlying hypertrichosis. More detailed information about the symptoms, causes, and treatments of beckers nevus is available below symptoms of beckers nevus. Becker s nevus associated with chromosomal mosaicism and congenital adrenal hyperplasia.
Becker nevus becker nevus also known as becker melanosis or becker pigmentary hamartoma is characterized by a circumscribed, brownish patch with geographical borders and sometimes hypertrichosis. Beckers nevus bn has been reported in association with smoothmuscle hamartoma, and an acneiform eruption and underlying structural anomalies of bone and soft tissues. David weedon ao md frcpa fcaphon, in weedons skin pathology third edition, 2010. Beckers nevus syndrome is a part of epidermal nevus syndrome, which. Becker nevus hairy epidermal nevus typically develops as a unilateral patch of hyperpigmentation on the shoulder, chest or back although any skin site may be involved. The lesion may present as single or multiple round or oval shaped, tan brown, uniform central nevi which is surrounded by a amelanotic ring upto several milimeters in width around the melanocytic naevus. The diagnosis is clinically based and the skin lesion must be present and no other numbered criteria. Pdf the simultaneous occurrence of a patch of light or dark brown. Halo nevus is a type melanocytic nevus which is usually noted in children and young adults. Lesions evolve with age, the initial lesion being macular with nests of proliferating.
May 22, 2007 histopathology skincellular blue nevus. Becker nevus syndrome is a phenotype characterized by the fundamental presence of beckers nevus with ipsilateral hypoplasia of the breast or other skin, skeletal. Acquired melanoyctic naevus or mole is a common benign tumour, usually appearing during childhood and adolescence. A rare skin disorder where an irregular pigmented patch on the skin slowly grows and becomes thick and hairy. The familial form of this condition is rare and we were unable to find any previous reports of its occurrence among siblings. Atypical presentation of beckers melanosis manoj j, kaliyadan f. Lesions evolve with age, the initial lesion being macular with nests of. In this report, a rare case of multiple becker nevi arranged in a. Beckers nevus syndrome in a pediatric female patient. Becker s nevus is a sharply demarcated tan to brown patch or slightly raised verrucous plaque that most commonly appears on the shoulder, chest, or upper back. Smooth muscle hamartoma associated with beckers nevus jama. Jul 31, 20 single rows of nevus cells in the septae of the subcutis looking for more information, highresolution images, or differential diagnoses on this entity. Histologically, ns displays mature or nearly mature sebaceus glands as well as acanthosis and. Nevus sebaceus ns and beckers nevus bn are two variants of epidermal nevi.
Beckers nevus genetic and rare diseases information center. Sep 26, 2012 there are several different types of epidermal nevi, including keratinocyte epidermal nevi, nevus sebaceous, nevus comedonicus, and becker nevus. Also called pigmented hairy epidermal nevus, beckers melanosis. Skin nonmelanocytic tumor beckers nevus beckers melanosis.
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